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CGT | Carrier Genetic Test by Igenomix
Learn moreIgenomix Genetic Counseling
Igenomix genetic counselors are licensed and certified healthcare professionals who provide patients and their clinical team with expert guidance on the genetic tests offered by Igenomix, including CGT options.
End-to End Support
They identify genetic risks, explain appropriate genetic testing options, discuss the implications of test results, and assist patients making informed genetic health care decisions.
Convenient & Flexible Service
Our genetic counselor team translates and communicates complex genetic information into practical, understandable terms.
Igenomix offers two types of counseling
Comprehensive Pre-Test Live Webinar
Igenomix offers a live webinar with certified genetic counselors to assist in the CGT process, providing:
- Patient education: Detailed information about genetic risks and appropriate testing options
- Support for informed Decision-making: Guidance to help patients make well-informed decisions.
- Test Accuracy and Limitations: Clear explanations of the accuracy and limitations of the test.
- Q&A Session: Dedicated time to answer any clinical questions you may have.
Post-Test CGT Results Appoinment
Join an online session with our genetic counselors, offering:
- Results discussion: In-depth conversation between the patient and the genetic counselor about the patient’s results.
- Risk Explanation: Detailed explanation of the identified genetic risks.
- Follow-up Testing Overview: Recommendations for any relevant follow-up testing based on the results.
Why to choose Igenomix’s Genetic Cousleror team?
Personalized Patient Support to meet your patient’s needs
Identify Genetic risks
Explain appropriate genetic testing options
Test results discussion
Support for informed decision-making
How does the testing Process work?
01.
Sample Collection
A blood or saliva sample is collected from reproductive partners.
02.
Complete TRF
Fill out the test requisition form through the Clinic Portal.
03.
Ship
Send the sample and completed TRF to Igenomix.
04.
Receive Report
The report will be available for download in your Clinic Portal within 20 bussines days from sample reception by Igenomix.
Saliva Sample Collection Instructions
Discover downloadable instructions for our CGT test available in various languages below.
Follow these steps carefully to ensure the accurate collection of DNA from saliva samples. Proper collection is crucial for obtaining high-quality genetic material for analysis.
FAQ’S
What is CGT | Carrier Genetic Test?
The CGT or Carrier Genetic Testing is a genetic tets which analyzes an individual’s DNA to determine if they are a carrier of a range of autosomal recessive genetic conditions. In biologically female individuals, carrier screening may also include the analysis of genes associated with X-linked conditions. This information can be useful in understanding the risk of having a child with a genetic condition.
Some genetic conditions occur more often in people who trace their ancestry to a particular geographic area. For example, Gaucher disease more frequently affects people of Ashkenazi Jewish ancestry, and sickle cell disease more frequently affects people of African descent. These conditions, however, are not restricted to these groups, and anyone can be a carrier.
Who should consider CGT?
According to the American College of Obstetricians and Gynecologists, carrier screening should be offered to pregnant individuals and to all individuals who are considering pregnancy, regardless of ethnicity and family history.
Carrier screening is available to anyone who wants to learn more about their risk of being a carrier of a genetic condition, including:
- Reproductive couples who are planning to conceive naturally.
- Individuals/couples who are planning an assisted reproduction.
- Patients planning a treatment with sperm/egg donors, and intended recipients of donor sperm/eggs.
- Reproductive couples at increased risk for a specific disorder based on their ethnicity.
What it means to be a “carrier” of a genetic disorder?
A carrier is an individual who has one mutated copy and one normal copy of the same gene.
When a child is conceived, they inherit half of their DNA from each biological parent, resulting in two copies of most genes. However, when variations or alterations manifest in the DNA, genes may fail to function properly, potentially leading to genetic disorders.
Being a carrier of a genetic condition typically does not impact your health because you have another functional copy of the gene, compensating for any changes in the affected one.
Interestingly, many of us are carriers of genetic conditions, but since our health is not usually affected, often remain unaware of our carrier status until undergoing specific genetic screening.
It is not unusual to be the first person in your family to know you’re carrier of a particular disorder. Your chance of being identified as a carrier depends on how many disorders you were screened for, your ethnic background, and your family history.
What is the risk of having an affected child?
Approximately 1-5% of reproductive couples are at risk of having an affected child, either because they are both carriers of the same autosomal recessive condition, or because the egg-source is a carrier of an X-linked condition.
Autosomal recessive inheritance
If both biological parents (individuals who provide the sperm and egg) carry a harmful variant in the same gene, with each pregnancy there is a 25% or 1 in 4 chance that the child will inherit two harmful variants (one from each biological parent) and be affected with the condition.
X-linked inheritance
If the biological mother (the individual providing the egg) is a carrier of an X-linked condition, there is a 25% or 1 in 4 chance of having an affected male and a 25% or 1 in 4 chance of having a carrier female.
What is an Autosomal Recessive Genetic Condition?
For autosomal recessive genetic conditions, the gene in question is located on
one of the ‘autosomes’ (chromosomes 1-22). A recessive genetic condition is
caused by an individual having a harmful spelling mistake (or ‘variant’) in both
copies of a particular gene.
If an individual has one copy of the gene with a harmful variant and a second,
working copy of the gene, they will be a ‘carrier’ of the condition. This generally
does not have any health implications as the working copy of the gene is able to
compensate for the faulty copy. It will, however, lead to an increased risk of
having a child with the related genetic condition, if the other biological parent
carries a harmful variant in the same gene. Research has shown that over 80%
of people are carriers of at least one genetic condition, often without knowing it.
Some examples of autosomal recessive conditions include cystic fibrosis (CF),
sickle cell anemia, and phenylketonuria (PKU).
What is an X-linked Condition?
X-linked conditions are caused by a harmful variant in a gene located on the X chromosome. As biological females have two X chromosomes, they usually have a second working copy of the gene which can compensate for the faulty copy.
Females with one faulty copy of the gene are considered carriers and can pass the faulty copy on to the next generation. Typically, female carriers are not affected by X-linked conditions, though for some conditions they may develop mild symptoms.
As biological males have only one X chromosome, there is no second copy of the gene to compensate for a faulty copy. If they have a harmful variant in a gene on this chromosome, they will be affected by the related X-linked condition.
Some examples of X-linked conditions include hemophilia, Duchenne muscular dystrophy (DMD), and fragile X- syndrome.
When will my results from the CGT become available?
Once the sample is received at Igenomix, the results will be available in 20 bussines days.
How can I contact a genetic professional to discuss my results?
Once the CGT test is completed, our genetic counselors are available to discuss the implications of the test results and answer any additional questions.
Why you should choose CGT by Igenomix?
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