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EMMA Endometrial Microbiome Metagenomic Analysis

The most comprehensive and precise panel, encompassing the most frequently detected and clinically relevant bacteria to evaluate the endometrium at the microbiological level

Overview

Upgraded EMMA
Benefits
Indications

What is the EMMA – Endometrial Microbiome Metagenomic Analysis?

EMMA is a test that analyses the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
EMMA assesses the endometrial microbiome, providing information about the most common and relevant bacteria, including those linked to higher pregnancy rates. EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.
Igenomix has analysed over 70,000 clinical samples during the last 5 years.
Through our experience with the EMMA&ALICE tests, we have identified the bacterial pathogens most frequently detected in the endometrium.
Based on this data, we have developed the most comprehensive and precise panel, encompassing all clinically relevant bacteria, with most identified at the species level, enabling a more precise and targeted treatments.

What is the procedure?

Why use the EMMA test?

EMMA uses RT-PCR technology to provide endometrial microbiome information by analysing the presence and quantity of the most common and relevant bacterial pathogens of the reproductive tract.
EMMA can also determine the abundance of Lactobacillus present in the endometrium; low proportions of Lactobacillus is associated with poor reproductive outcomes.
EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.
EMMA determines whether the endometrial microbial environment is optimal or not for embryo implantation.
If the endometrial microbial environment is not optimal for embryo implantation, a recommendation for a precise and targeted treatment is provided.

Who should use the EMMA?

Patients with repeated implantation failure (RIF)
Patients with repeated pregnancy loss (RPL)
EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation

*Moreno et al., 2016

Test limitations:

These tests are not able to detect resistance to antibiotics
A negative result doesn’t rule out the presence of other endometrial pathogens

Documentation

EMMA Specialists' documents

Relevant related studies:

Iwami et al. Therapeutic intervention based on gene sequencing analysis of microbial 16S ribosomal RNA of the intrauterine microbiome improves pregnancy outcomes in IVF patients: a prospective cohort study. J Assist Reprod Genet. 2023 Jan;40(1):125-135. doi: 10.1007/s10815-022-02688-6.

Moreno et al. The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018 Jun;218(6):602.e1-602.e16. doi: 10.1016/j.ajog.2018.02.012.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234.

Moreno et al. Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazán J, Alonso R, Alamá P, Remohí J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016 Dec;215(6):684-703. doi: 10.1016/j.ajog.2016.09.075. Epub 2016 Oct 4. PMID: 27717732.

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EMMA Endometrial Microbiome Metagenomic Analysis

The most comprehensive and precise panel, encompassing the most frequently detected and clinically relevant bacteria to evaluate the endometrium at the microbiological level

30% of infertile women have pathogenic bacteria detected in their endometrium

Upgraded EMMA panel: the most precise panel available, developed after analysing over 70,000 clinical samples during the last 5 years

The upgraded EMMA panel now identifies bacteria at the species level, enabling more precise and targeted treatments

What is the EMMA – Endometrial Microbiome Metagenomic Analysis?

What is the procedure?

Why use the EMMA test?

Who should use the EMMA?

Test limitations:

Clinical Sheets

Brochure

EndomeTRIO Manual

Instructions

Relevant related studies:

FAQs

Can we help you?

Igenomix and fertility

ERA

EMMA Endometrial Microbiome Metagenomic Analysis

The most comprehensive and precise panel, encompassing the most frequently detected and clinically relevant bacteria to evaluate the endometrium at the microbiological level

30% of infertile women have pathogenic bacteria detected in their endometrium

Upgraded EMMA panel: the most precise panel available, developed after analysing over 70,000 clinical samples during the last 5 years

The upgraded EMMA panel now identifies bacteria at the species level, enabling more precise and targeted treatments

What is the EMMA – Endometrial Microbiome Metagenomic Analysis?

What is the procedure?

Why use the EMMA test?

Who should use the EMMA?

Test limitations:

Clinical Sheets

Brochure

EndomeTRIO Manual

Instructions

Relevant related studies:

FAQs

Can we help you?

Igenomix and fertility

Other services

ERA

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