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Genetic Solutions > Emma

EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

EMMA Endometrial Microbiome Metagenomic
  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist
CGT Carrier Genetic Test

20% of infertility is caused by the endometrial factor

EMMA Endometrial Microbiome Metagenomic

30% of infertile women have pathogenic bacteria

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Or Email us at nacespain@igenomix.com
Overview
  • EMMA
  • Benefits
  • Indications

What is the EMMA – Endometrial Microbiome Metagenomic Analysis test?

  • EMMA is a test that analyses the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
  • EMMA indicates the endometrial microbiome balance, providing information on the proportions of all endometrial bacteria, including those linked to higher pregnancy rates. EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.

What is the procedure?

implantation failure
  • EMMA can be performed on a small piece of an endometrial biopsy.

Why use EMMA test?

  • EMMA is a molecular technique that provides endometrial microbiome information by analysing the complete profile of the bacteria present in the tissue
  • EMMA can determine the percentage of Lactobacillus present in the endometrium; low proportions of Lactobacillus are associated with poor reproductive outcomes
  • EMMA includes the ALICE test, so it indicates the possible presence of bacteria that can cause chronic endometritis, further other pathogenic bacteria.
  • If the endometrium is non-Lactobacillus dominated, the report will suggest the adequate treatment for each patient
  • EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation

Who should use the EMMA?

  • Patients with repeated implantation failure (RIF)
  • EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation

*Moreno et al., 2016

Test limitations:

  • These tests are not able to detect resistance to antibiotics
  • The tests are not 100% accurate at determining the bacterial species.
  • A negative result doesn’t rule out the presence of other endometrial pathogens
Documentation
  • EMMA Specialists' documents

Clinical Sheets

Download

Brochure

Download

EndomeTRIO Manual

Download

Instructions

Download
Scientific evidence

Relevant related studies:

Moreno et al. Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w.

Evidence that the endometrial microbiota has an effect on implantation success or failure. Moreno, Inmaculada et al. American Journal of Obstetrics & Gynecology, Volume 215, Issue 6, 684 – 703.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14. 

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Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.

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Other services

ERA

Evaluates the endometrial receptivity

More information
EndomeTRIO

EndomeTRIO

A new dimension of endometrial health

More information

ALICE

Detects the bacteria causing chronic endometritis

More information

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  • We guide you
    • Fertility
      • What to do if…
    • Prevent Inherited Diseases
      • Carrier Genetic Test
    • Worry-free Pregnancy
      • NACE
      • Prenatal Diagnostics
      • Newborn Health
  • Reproductive Health
    • Specialists
      • ALICE
      • EMMA
      • ERA
      • EndomeTRIO
      • EMBRACE
      • CGT
      • NACE
      • Zenit
      • PGT-A
      • PGT-M
      • POC
      • SAT
      • Newborn Screening
    • Patients
      • ALICE
      • EMMA
      • ERA
      • EndomeTRIO
      • EMBRACE
      • CGT
      • NACE
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      • PGT-A
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      • SAT
      • POC
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