The first step towards securing your family’s future…
CGT | Carrier Genetic Test by Igenomix
Allows for testing of all known recessive conditions
Matching possible will ALL competitor tests in the market
Any upgrade possible at a later date if required
Backed by strongest scientific and clinical support team in the market
What it means to be a “carrier” of a genetic disorder?
- When a child is conceived, they inherit half of their DNA from each biological parent, resulting in two copies of most genes. However, when variations or alterations manifest in the DNA, genes may fail to function properly, potentially leading to genetic disorders.
- Being a carrier of a genetic condition typically does not impact your health because you have another functional copy of the gene, compensating for any changes in the affected one.
- Interestingly, many of us are carriers of genetic conditions, but since our health is not usually affected, often remain unaware of our carrier status until undergoing specific genetic screening.
- It is not unusual to be the first person in your family to know you’re carrier of a particular disorder.
What is CGT Test?
- Carrier Genetic Testing with Igenomix analyzes an individual’s DNA to determine if they are a carrier of a range of autosomal recessive genetic conditions. In biologically female individuals, carrier screening may also include the analysis of genes associated with X-linked conditions. This information can be useful in understanding the risk of having a child with a genetic condition.
- Some genetic conditions occur more often in people who trace their ancestry to a particular geographic area. For example, Gaucher disease more frequently affects people of Ashkenazi Jewish ancestry, and sickle cell disease more frequently affects people of African descent. These conditions, however, are not restricted to these groups, and anyone can be a carrier.
Who should consider CGT?
According to the American College of Obstetricians and Gynecologists (ACOG),
carrier screening should be offered to all women who are considering pregnancy or are currently pregnant, regardless of ethnicity and family history.
Carrier screening is available to anyone who wants to learn more about their risk of being a carrier of a genetic condition, including:
- Reproductive couples who are planning to conceive naturally.
- Individuals/couples who are planning an assisted reproduction.
- Patients planning a treatment with sperm/egg donors, and intended recipients of donor sperm/eggs.
- Reproductive couples at increased risk for a specific disorder based on their ethnicity.
How does CGT work?
01.
Sample Collection:
A blood or saliva sample is collected from reproductive partners.
02.
DNA Analysis:
The sample is sent to Igenomix and DNA is extracted to analyze the entire exome and reports a wide panel of disorders including Cystic Fibrosis, Spinal Muscular Atrophy, and Fragile-X Syndrome.
03.
Results:
The report will be available for download in your Clinic Portal within 20 bussines days from sample reception by Igenomix.
What do the results mean?
The following results can be obtained as a result of performing this test:
If an individual receives a negative CGT result, this means they have not been found to be a carrier of any of the conditions included in the test. This does not exclude the possibility that the individual carries a harmful variant in a gene that was not tested.
If both biological parents are found to be carriers of the same autosomal recessive condition, or the biological mother is a carrier of an X-linked condition, there is an increased risk of having an affected child.
No test can detect all possible carriers, so there´s still a small chance that you are a carrier. This is called residual risk. Your report will list your residual risks for each of the disorders tested.
Reproductive options for at-risk couples:
If the result shows that the reproductive couple is at increased risk of having a child with one of the disorders on the CGT, a follow-up genetic counseling session is available to explore potential reproductive options. These options may include:
- Continuing with reproductive plans with an understanding of the risk
- Sperm/egg donation or selection of an alternative donor
- Genetic testing of embryos and selection of unaffected embryos for transfer (pre-implantation genetic testing)
- Genetic testing in pregnancy to determine whether the developing fetus is affected (prenatal testing)
- Adoption
Which CGT test is right for me?
- To fit the needs of all patients and healthcare providers, different CGT ordering options are available.
- We have designed different carrier screening panels, from a small to a large gene panel to accommodate specific needs.
CGT Personalized
This is a test that facilitates “mirroring” a carrier screening test performed by a different genetic testing laboratory to ensure that the two panels include the same genes.
Panels can vary between laboratories and over time. CGT Mirror can be considered when one member of the reproductive couple has already had carrier screening and the other member wishes to have a similar panel of genes tested.
CGT Sync
This test may be considered when one individual in a reproductive couple (one partner or a sperm/egg donor) is a known carrier of one or more autosomal recessive genetic conditions. CGT Sequential can be ordered for the reproductive partner and includes analysis of the gene(s) of interest. The optional analysis of X-linked conditions is available for biologically female patients.
CGT Plus and CGT Exome
These are tests that examine a larger list of genes associated with over 500 and 2000 genetic conditions, respectively. These panel-based tests are recommended when both individuals in a reproductive couple are seeking CGT to find out if they might be carriers of the same genetic condition(s), or when individuals are looking to donate eggs/sperm.
CGT Bank
This screening test is designed to detect the prevalent genetic conditions commonly observed within the general population. It comes highly recommended for screening purposes by both the American College of Obstetricians and Gynecologists (ACOG) and the American College of Medical Genetics and Genomics (ACMG).
Why you should choose CGT by Igenomix?
Clinical advantage
Enables testing of all known recessive conditions and lowers residual risk by increasing the overall detection rate through Exome sequencing.
Matching
Maximizes IVF applications by enabling seamless compatibility with ALL competitor tests in the market, eliminating the need for any resequencing.
Upgrades
Any upgrade possible at a later date if required.
Scientific support
Igenomix provides the strongest scientific team in the market, including Genetic Counselors (available both before and after the test), scientific advisors, dedicated CGT specialists, and in-house clinicians to support you all the way.
Other services
PGT-M
(Preimplantation Genetic Testing for Monogenic disorders)
PGT-M helps couples with a risk of transmitting a genetic disease. This genetic test Prevents the transmission of inherited disorders to future children and achieve a healthy pregnancy.
More informationPGT-A
(Preimplantation Genetic Testing for Aneuploidies)
Is a genetic test performed embryos obtained with IVF thathelps you to have a successful pregnancy and a healthy baby. PGT-A increases the chances of an ongoing healthy and pregnancy.
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Identifying the genetic causes of infertility.
An advanced genetic test designed to detect the most common genetic mutations linked to infertility
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