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      Genetic Solutions > ALICE

      ALICE Analysis of Infectious Chronic Endometritis

      ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

      chronic endometritis
      • Technical Overview
      • Documentation
      • Scientific evidence
      • I’m not a health specialist
      CGT Carrier Genetic Test

      20% of infertility is caused by the endometrial factor.

      EMMA Endometrial Microbiome Metagenomic

      Chronic endometritis affects up to 30% of infertile patients.

      igenomix

      In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

      Interested in learning more?

      Request information
      Or Email us at supportspain@igenomix.com
      Overview
      • ALICE
      • Benefits
      • Indications

      What is ALICE test?

      • ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.
      • Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.
      • In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

      What is the procedure?

      • ALICE can be performed on a small piece of an endometrial biopsy.

      Why use ALICE?

      • ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment
      • ALICE uses the latest Next Generation Sequencing (NGS) technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis
      • Using NGS allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis
      • If the ALICE test is positive, the report will focus on the detection of the specific bacteria causing the condition
      • A recommendation of the most appropriate antibiotic is made based on the bacteria detected.
      • Microbiology counselling is available

      Who should use ALICE?

      • ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
      • ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

      Test limitations:

      • This test is not able to detect resistance to antibiotics.
      • ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out  the presence of other endometrial pathogens.
      • This test is not 100% accurate at determining the bacterial species.
      Documentation & Resources
      • ALICE Specialists' documents

      Clinical Sheets

      Download

      Brochure

      Download

      EndomeTRIO Manual

      Download

      Instructions

      Download
      Scientific evidence

      Relevant related studies:

      Moreno et al. Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w.

      Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

      Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016; 215:684-703. 

      Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C. The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012. 

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      Igenomix and fertility

      We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.

      Learn more about Igenomix

      Other services

      ERA

      Evaluates the endometrial receptivity

      More information
      EMMA Endometrial Microbiome Metagenomic

      EMMA

      Evaluates the endometrium at the microbiological level

      More information
      EndomeTRIO

      EndomeTRIO

      A new dimension of endometrial health

      More information

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          • What to do if…
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