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      Genomics Precision Diagnostic > Nephrology > Hemolytic Uremic Syndrome Precision Panel

      Hemolytic Uremic Syndrome Precision Panel

      Hemolytic Uremic Syndrome (HUS) is defined by the presence of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is one of the main causes of acute kidney injury in children.
      Overview
      Indication
      Clinical Utility
      Genes & Diseases
      Methodology
      References

      Overview

      • Hemolytic Uremic Syndrome (HUS) is defined by the presence of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is one of the main causes of acute kidney injury in children. It is a clinically heterogeneous condition given the different etiologies of HUS that result in differences in presentation, management and outcome. It has been classified into typical HUS resulting from Shiga toxin-producing E.coli infections (STEC) and atypical HUS or non-STEC. HUS can be hereditary due to inborn errors of cobalamin C metabolism, complement gene mutations or acquired by infections, autoantibodies or drug toxicity. It is estimated that approximately 50 percent of non-Shiga-toxin-producing E.coli cases result from mutations in these genes. There is a seasonal pattern of HUS, peaking in the summer and fall. The mode of inheritance follows an autosomal dominant or autosomal recessive pattern.  

      • The Igenomix Hemolytic Uremic Syndrome Precision Panel can be used to make a directed and accurate diagnosis ultimately leading to a better management and prognosis of the disease. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.

      Indication

      • The Igenomix Hemolytic Uremic Syndrome Precision Panel is indicated for those patients with a clinical suspicion or diagnosis presenting with or without the following manifestations: 
        • Gastroenteritis: fever, bloody diarrhea 
        • Irritability 
        • Lethargy 
        • Seizures 
        • Acute renal failure 
        • Anuria 
        • Hypertension 
        • Edema 
        • Pallor 

      Clinical Utility

      The clinical utility of this panel is: 

      • The genetic and molecular confirmation for an accurate clinical diagnosis of a symptomatic patient.  
      • Early initiation of treatment with a multidisciplinary team in the form of plasma exchange therapy, red blood cell transfusions, appropriate fluid and electrolyte management, provision of adequate nutrition.  
      • Risk assessment of asymptomatic family members according to the mode of inheritance. 
      • Improvement of delineation of genotype-phenotype correlation. 

      Genes & Diseases

      Methodology

      References

      See scientific referrals

      Noris, M., & Remuzzi, G. (2005). Hemolytic Uremic Syndrome. Journal Of The American Society Of Nephrology, 16(4), 1035-1050. doi: 10.1681/asn.2004100861 

      Fakhouri, F., Zuber, J., Frémeaux-Bacchi, V., & Loirat, C. (2017). Haemolytic uraemic syndrome. The Lancet, 390(10095), 681-696. doi: 10.1016/s0140-6736(17)30062-4 

      Loirat, C., Fakhouri, F., Ariceta, G., Besbas, N., Bitzan, M., & Bjerre, A. et al. (2015). An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatric Nephrology, 31(1), 15-39. doi: 10.1007/s00467-015-3076-8 

      Keir, L. (2015). Shiga Toxin Associated Hemolytic Uremic Syndrome. Hematology/Oncology Clinics Of North America, 29(3), 525-539. doi: 10.1016/j.hoc.2015.01.007 

      Siegler, R., & Oakes, R. (2005). Hemolytic uremic syndrome; pathogenesis, treatment, and outcome. Current Opinion In Pediatrics, 17(2), 200-204. doi: 10.1097/01.mop.0000152997.66070.e9 

      Taylor, C., Machin, S., Wigmore, S., & Goodship, T. (2010). Clinical Practice Guidelines for the management of atypical Haemolytic Uraemic Syndrome in the United Kingdom. British Journal Of Haematology, 148(1), 37-47. doi: 10.1111/j.1365-2141.2009.07916.x 

      Cody, E. M., & Dixon, B. P. (2019). Hemolytic Uremic Syndrome. Pediatric clinics of North America, 66(1), 235–246. https://doi.org/10.1016/j.pcl.2018.09.011 

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      • We guide you
        • Fertility
          • What to do if…
        • Prevent Inherited Diseases
          • Carrier Genetic Test
        • Worry-free Pregnancy
          • NACE
          • Prenatal Diagnostics
          • Newborn Health
      • Reproductive Health
        • Specialists
          • ALICE
          • EMMA
          • ERA
          • EndomeTRIO
          • EMBRACE
          • CGT
          • NACE
          • Zenit
          • PGT-A
          • PGT-M
          • POC
          • SAT
          • Newborn Screening
        • Patients
          • ALICE
          • EMMA
          • ERA
          • EndomeTRIO
          • EMBRACE
          • CGT
          • NACE
          • Zenit
          • PGT-A
          • PGT-M
          • SAT
          • POC
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