Juvenile arthritis is a heterogenous group of inflammatory arthritis of unknown etiology, all defined by the presence of at least one inflamed joint persisting more than six weeks. Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease in children, with an unpredictable clinical course and the impending risk of impaired joint function. It begins before 16 years of age, and the triggering factor can be a trauma or infection. JIA can be classified in six categories:
Polyarthritis (rheumatoid factor positive or negative)
The prognosis varies depending on the case, but systemic arthritis and rheumatoid factor positive polyarthritis generally show a worse prognosis. The most common mode of inheritance is autosomal recessive.
The Igenomix Juvenile Idiopathic Arthritis Precision Panel can be used to make an accurate and directed diagnosis as well as a differential diagnosis of arthritis ultimately leading to a better management and prognosis of the disease. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.
The clinical utility of this panel is:
- The genetic and molecular confirmation for an accurate clinical diagnosis of a symptomatic patient.
- Early initiation of multidisciplinary treatment including occupational and physical therapist, pharmacologic treatment with anti-inflammatory drugs to reduce pain and swelling, or even disease-modifying antirheumatic drugs (DMARDs) if there is a high risk of damage in the future.
- Risk assessment and genetic counselling of asymptomatic family members according to the mode of inheritance.
- Improvement of delineation of genotype-phenotype correlation.
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