Nervous System Cancer Precision Panel
- Nervous system cancers are a group of neoplasms that include all types of tumours that develop in the peripheral or central nervous system. Several inherited genetic disorders predispose to the development of neoplasms of the nervous system. These hereditary cancer syndromes comprise a varied group of conditions that include neurofibromatosis types 1 and 2, Cowden syndrome, Li-Fraumeni syndrome, Gorlin syndrome, multiple endocrine neoplasia type 1, tuberous sclerosis complex, von Hippel–Lindau disease, and Turcot syndrome. Recognition of individuals and families at increased risk for such inherited tumours is critical to improve clinical care and optimize proper genetic counselling.
- As many of the oncologists are used to group and study the different cancer types in systems or specialities, the main objective of this product is to provide them with a more manageable diagnostic tool according to their field of knowledge.
The Igenomix Nervous System Cancer Panel is indicated in those cases in which the physician is suspecting of a hereditary cancer syndrome. It is designed to diagnose individuals with a personal or family history suggestive of inherited cancer in the nervous system, providing important information that may impact cancer treatment as well as cancer risk assessment and management.
- Identify pathogenic cancer susceptibility variants
- Maximize surveillance and preventive strategies for at risk individuals
- Provide options and strategies for targeted treatment, therapeutic planning, and clinical trials
- Perform risk assessment and genetic counselling for family members (cascade testing)
Miller, K. D., Ostrom, Q. T., Kruchko, C., Patil, N., Tihan, T., Cioffi, G., Fuchs, H. E., Waite, K. A., Jemal, A., Siegel, R. L., & Barnholtz-Sloan, J. S. (2021). Brain and other central nervous system tumor statistics, 2021. CA: a cancer journal for clinicians, 71(5), 381–406. https://doi.org/10.3322/caac.21693
Shahab, S., & Fangusaro, J. (2021). Neonatal Central Nervous System Tumors. Clinics in perinatology, 48(1), 35–51. https://doi.org/10.1016/j.clp.2020.11.003
Coserria Sánchez, J. F., Garrido Ocaña, A. I., Quiroga Cantero, E., Reina González, A. M., Amadeu Da Costa, A. P., & García Zarza, N. (2007). Clínica de presentación de los tumores de sistema nervioso central en función de la edad [Presenting signs and symptoms of central nervous system tumors according to age]. Anales de pediatria (Barcelona, Spain : 2003), 66(2), 115–120. https://doi.org/10.1157/13098927
Alteri, R., & Kalidas, M. (2020). Signs and symptoms of adult brain and spinal cord tumors. Retrieved January 8, 2022, from cancer.org website: https://www.cancer.org/es/cancer/tumores-de-encefalo-o-de-medula-espinal/deteccion-diagnostico-clasificacion-por-etapas/senales-y-sintomas.html
Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2020). Brain immunology and immunotherapy in brain tumours. Nature reviews. Cancer, 20(1), 12–25. https://doi.org/10.1038/s41568-019-0224-7 Shen, C. J., Perkins, S. M., Bradley, J. A., Mahajan, A., & Marcus, K. J. (2021). Radiation therapy for infants with cancer. Pediatric blood & cancer, 68 Suppl 2, e28700. https://doi.org/10.1002/pbc.28700
Radiographics . Jan-Feb 2017;37(1):258-280. doi: 10.1148/rg.2017160057. Epub 2016 Dec 2. Genetic Syndromes Associated with Central Nervous System Tumors
Neurol Clin . 2007 Nov;25(4):925-46, viii. doi: 10.1016/j.ncl.2007.07.008. Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes
Neurosurg Clin N Am . 2022 Jan;33(1):91-104. doi: 10.1016/j.nec.2021.09.007. Epub 2021 Oct 26. Tumor Syndromes: Neurosurgical Evaluation and Management