Genomics Precision Diagnostic > Oncology > Nervous System Cancer Precision Panel

Nervous System Cancer Precision Panel

The Igenomix Nervous System Precision Panel has been designed to carry out an accurate and effective diagnosis of hereditary cancer syndromes related to nervous system. It provides a comprehensive analysis of the most important genes associated with these types of cancer using next-generation sequencing.

Overview

Indication

Clinical Utility

Genes & Diseases

Methodology

References

Overview

Nervous system cancers are a group of neoplasms that include all types of tumours that develop in the peripheral or central nervous system. Several inherited genetic disorders predispose to the development of neoplasms of the nervous system. These hereditary cancer syndromes comprise a varied group of conditions that include neurofibromatosis types 1 and 2, Cowden syndrome, Li-Fraumeni syndrome, Gorlin syndrome, multiple endocrine neoplasia type 1, tuberous sclerosis complex, von Hippel–Lindau disease, and Turcot syndrome. Recognition of individuals and families at increased risk for such inherited tumours is critical to improve clinical care and optimize proper genetic counselling.
As many of the oncologists are used to group and study the different cancer types in systems or specialities, the main objective of this product is to provide them with a more manageable diagnostic tool according to their field of knowledge.

Indication

The Igenomix Nervous System Cancer Panel is indicated in those cases in which the physician is suspecting of a hereditary cancer syndrome. It is designed to diagnose individuals with a personal or family history suggestive of inherited cancer in the nervous system, providing important information that may impact cancer treatment as well as cancer risk assessment and management.

Clinical Utility

The clinical utility of this panel is:

Identify pathogenic cancer susceptibility variants
Maximize surveillance and preventive strategies for at risk individuals
Provide options and strategies for targeted treatment, therapeutic planning, and clinical trials
Perform risk assessment and genetic counselling for family members (cascade testing)

Genes & Diseases

Methodology

References

See scientific referrals

Miller, K. D., Ostrom, Q. T., Kruchko, C., Patil, N., Tihan, T., Cioffi, G., Fuchs, H. E., Waite, K. A., Jemal, A., Siegel, R. L., & Barnholtz-Sloan, J. S. (2021). Brain and other central nervous system tumor statistics, 2021. CA: a cancer journal for clinicians, 71(5), 381–406. https://doi.org/10.3322/caac.21693

Shahab, S., & Fangusaro, J. (2021). Neonatal Central Nervous System Tumors. Clinics in perinatology, 48(1), 35–51. https://doi.org/10.1016/j.clp.2020.11.003

Coserria Sánchez, J. F., Garrido Ocaña, A. I., Quiroga Cantero, E., Reina González, A. M., Amadeu Da Costa, A. P., & García Zarza, N. (2007). Clínica de presentación de los tumores de sistema nervioso central en función de la edad [Presenting signs and symptoms of central nervous system tumors according to age]. Anales de pediatria (Barcelona, Spain : 2003), 66(2), 115–120. https://doi.org/10.1157/13098927

Alteri, R., & Kalidas, M. (2020). Signs and symptoms of adult brain and spinal cord tumors. Retrieved January 8, 2022, from cancer.org website: https://www.cancer.org/es/cancer/tumores-de-encefalo-o-de-medula-espinal/deteccion-diagnostico-clasificacion-por-etapas/senales-y-sintomas.html

Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2020). Brain immunology and immunotherapy in brain tumours. Nature reviews. Cancer, 20(1), 12–25. https://doi.org/10.1038/s41568-019-0224-7 Shen, C. J., Perkins, S. M., Bradley, J. A., Mahajan, A., & Marcus, K. J. (2021). Radiation therapy for infants with cancer. Pediatric blood & cancer, 68 Suppl 2, e28700. https://doi.org/10.1002/pbc.28700

Radiographics . Jan-Feb 2017;37(1):258-280. doi: 10.1148/rg.2017160057. Epub 2016 Dec 2. Genetic Syndromes Associated with Central Nervous System Tumors

Neurol Clin . 2007 Nov;25(4):925-46, viii. doi: 10.1016/j.ncl.2007.07.008. Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes

Neurosurg Clin N Am . 2022 Jan;33(1):91-104. doi: 10.1016/j.nec.2021.09.007. Epub 2021 Oct 26. Tumor Syndromes: Neurosurgical Evaluation and Management

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Nervous System Cancer Precision Panel

Overview

Indication

Clinical Utility

Genes & Diseases

Methodology

References

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