Alzheimer Disease (AD) is the most common cause of dementia and one of the leading causes of morbidity and mortality in the aging population. The main clinical characteristic of AD is dementia that typically begins with subtle and poorly recognized failure of memory also known as mild cognitive impairment, slowly becoming more severe and eventually incapacitating. Other findings include confusion, disorientation, language disturbances, agitation etc. 95% of all AD is late onset, typically over the age of 60-65, however, 5% is early onset. Approximately 25% of all AD is familial and 75% is nonfamilial. Familial forms of AD have a strong genetic predisposition. While the pathogenesis of AD remains unclear, all forms of AD appear to share overproduction and/or decreased clearance of amyloid beta peptides. The modes of inheritance of familial forms of AD are autosomal dominant and recessive patterns.
The Igenomix Alzheimer Disease Precision Panel can be used as a tool for an accurate diagnosis and differential diagnosis of dementia ultimately leading to a better management and prognosis of the disease. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved, and their high or intermediate penetrance.
The clinical utility of this panel is:
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