Skip to content
  • Argentina
  • Brazil
  • Canada
  • Chile
  • Colombia
  • Europe
  • France
  • Germany
  • India
  • Italy
  • Japan
  • Korea
  • Mexico
  • Perú
  • Russia
  • Spain
  • Taiwan
  • The Middle East
  • Turkey
  • United Kingdom
  • United States
  • Vietnam
  • Country/Region
    • Clinic Portal
      • +0034963905310
    • Request Information
    • +34 96 390 53 10
    InternationalInternational
    • Country/Region
    • We guide you
      • Fertility
        • What to do if…
      • Prevent Inherited Diseases
        • Carrier Genetic Test
      • Worry-free Pregnancy
        • NACE
        • Prenatal Diagnostics
        • Newborn Health
    • Reproductive Health
      • Specialists
        • ALICE
        • EMMA
        • ERA
        • EndomeTRIO
        • EMBRACE
        • CGT
        • NACE
        • Zenit
        • PGT-A
        • PGT-M
        • POC
        • SAT
        • Newborn Screening
      • Patients
        • ALICE
        • EMMA
        • ERA
        • EndomeTRIO
        • EMBRACE
        • CGT
        • NACE
        • Zenit
        • PGT-A
        • PGT-M
        • SAT
        • POC
    • Diagnostics
    • About us
      • Igenomix Research
      • About Igenomix
    • Academy
    • Blog
        Genomics Precision Diagnostic > Cardiology > Sudden Cardiac Death Precision Panel

        Sudden Cardiac Death Precision Panel

        Sudden Cardiac Death (SCD) is an unexpected death due to cardiac causes that takes place in a short time period in a person with known or unknown underlying cardiac disease.
        Overview
        Indication
        Clinical Utility
        Genes & Diseases
        Methodology
        References

        Overview

        • Sudden Cardiac Death (SCD) is an unexpected death due to cardiac causes that takes place in a short time period in a person with known or unknown underlying cardiac disease. It is an important public-health problem with multiple etiologies, risk factors and changing temporal trends. The overwhelming sadness suffered by families is heightened by the risk many of these deaths confer upon surviving relatives. For those with known cardiac disease, disease-specific therapy and risk stratification are key to reducing sudden cardiac death. Uncovering a definitive cause of death can help relieve the uncertainty as a first step in screening surviving relatives. Increasing knowledge about the molecular mechanisms and genetic drivers of malignant arrythmias have become a key component in achieving a risk stratification system to optimize and personalize patient care.
        • The Igenomix Sudden Cardiac Death Precision Panel serves as a diagnostic and screening tool ultimately leading to a preventive approach of the disease by risk stratification. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes.  

        Indication

        • The Igenomix Sudden Cardiac Death Precision Panel is indicated in those cases where there are a series of risk factors that could precipitate SCD including:
          • Family history of premature coronary artery disease 
          • Family history of cardiomyopathy  
          • Family history of malignant arrythmia 
          • Family history of SCD 
          • Personal history of cardiovascular risk factors 
            • Smoking 
            • Dyslipidemia 
            • Hyeprtension 
            • Diabetes 
            • Obesity 
            • Sedentary lifestyle 

        Clinical Utility

        The clinical utility of this panel is: 

        • The genetic and molecular diagnosis for an accurate clinical diagnosis. 
        • Early initiation of treatment in case risk factors are present (smoking, diabetes, dyslipidemia, hyerptension etc)
        • Early prevention with a multidisciplinary team in the form of preventive ICD placement, pacemaker, pharmacologic therapy, or interventional procedures. 
        • Risk assessment and genetic counselling of asymptomatic family members  according to the mode of inheritance. 

        Genes & Diseases

        Methodology

        References

        See scientific referrals

        Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J., & Page, R. L. (2018). 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology, 72(14), e91–e220. https://doi.org/10.1016/j.jacc.2017.10.054 

        Isbister, J., & Semsarian, C. (2019). Sudden cardiac death: an update. Internal medicine journal, 49(7), 826–833. https://doi.org/10.1111/imj.14359 

        Schwartz, P. J., Ackerman, M. J., George, A. L., Jr, & Wilde, A. (2013). Impact of genetics on the clinical management of channelopathies. Journal of the American College of Cardiology, 62(3), 169–180. https://doi.org/10.1016/j.jacc.2013.04.044  

        Hershberger, R. E., Givertz, M. M., Ho, C. Y., Judge, D. P., Kantor, P. F., McBride, K. L., Morales, A., Taylor, M., Vatta, M., Ware, S. M., & ACMG Professional Practice and Guidelines Committee (2018). Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genetics in medicine : official journal of the American College of Medical Genetics, 20(9), 899–909. https://doi.org/10.1038/s41436-018-0039-z  

        Haïssaguerre, M., Derval, N., Sacher, F., Jesel, L., Deisenhofer, I., & de Roy, L. et al. (2008). Sudden Cardiac Arrest Associated with Early Repolarization. New England Journal Of Medicine, 358(19), 2016-2023. doi: 10.1056/nejmoa071968 

        Refaat, M., Hotait, M., & London, B. (2015). Genetics of Sudden Cardiac Death. Current Cardiology Reports, 17(7). doi: 10.1007/s11886-015-0606-8 

        Adabag, A. S., Luepker, R. V., Roger, V. L., & Gersh, B. J. (2010). Sudden cardiac death: epidemiology and risk factors. Nature reviews. Cardiology, 7(4), 216–225. https://doi.org/10.1038/nrcardio.2010.3 

        descargar

        Detail description

        Download

        Request Information


        WE GUIDE YOU

        Fertility
        Inherited diseases prevention
        Healthy pregnancy

        To see the accreditation certificate, associated technical annex and list of accredited tests, click on this link.

        OUR SERVICES

        Genetic solutions
        For patients
        How to send a sample?
        User manual

        ABOUT US

        About Igenomix
        Contact
        Quality
        Complaints
        Work with us

        FOLLOW IGENOMIX

          + 96 390 53 10
          Write us
        • Argentina
        • Brazil
        • Canada
        • Chile
        • Colombia
        • Europe
        • France
        • Germany
        • India
        • Italy
        • Japan
        • Korea
        • Mexico
        • Perú
        • Russia
        • Spain
        • Taiwan
        • The Middle East
        • Turkey
        • United Kingdom
        • United States
        • Vietnam
        Country/Region

        [2021] © Igenomix Privacy policy Quality policy Legal note Cookies policyNews and Press

        Request Information


        • We guide you
          • Fertility
            • What to do if…
          • Prevent Inherited Diseases
            • Carrier Genetic Test
          • Worry-free Pregnancy
            • NACE
            • Prenatal Diagnostics
            • Newborn Health
        • Reproductive Health
          • Specialists
            • ALICE
            • EMMA
            • ERA
            • EndomeTRIO
            • EMBRACE
            • CGT
            • NACE
            • Zenit
            • PGT-A
            • PGT-M
            • POC
            • SAT
            • Newborn Screening
          • Patients
            • ALICE
            • EMMA
            • ERA
            • EndomeTRIO
            • EMBRACE
            • CGT
            • NACE
            • Zenit
            • PGT-A
            • PGT-M
            • SAT
            • POC
        • Diagnostics
        • About us
          • Igenomix Research
          • About Igenomix
        • Academy
        • Blog
        • Country/Region
        • +34 96 390 53 10
        • Clinic Portal
        • Request Information

        We are using cookies to give you the best experience on our website.

        You can find out more about which cookies we are using or switch them off in settings.

        International
        Powered by  GDPR Cookie Compliance
        Privacy Overview

        This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.

        Strictly Necessary Cookies

        Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.

        If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.

        3rd Party Cookies

        This website uses Google Analytics to collect anonymous information such as the number of visitors to the site, and the most popular pages.

        Keeping this cookie enabled helps us to improve our website.

        Please enable Strictly Necessary Cookies first so that we can save your preferences!

        Cookie Policy

        More information about our Cookie Policy