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PGT-A Plus

PGT-A Plus

Our most advanced 4-in-1 genetic test offers increased accuracy and confidence for embryo transfer.

Combines two in-house validated technologies (NGS + SNPs analysis) 

Superior accuracy and enhanced confidence to detect any abnormalities

Increases the number of viable embryos available for transfer

Interested in learning more?

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Or Email us at supportspain@igenomix.com
Overview
  • To enhance the genetic testing of IVF embryos and expand the diagnostic capabilities and clinical utility of our preimplantation genetic testing for aneuploidy (PGT-A), we have developed and validated a parallel targeted Next-Generation Sequencing (NGS) strategy using the power of SNP technology with out the need for parental samples.
  • Single Nucleotide Polymorphisms (SNPs) are changes in single nucleotides distributed throughout the genome and frequently vary at the same genomic position between individuals. Most SNPs have only two different alleles.
  • SNPs can be used to detect ploidy differences, DNA
    contamination and confirm genetic relatedness between
    samples in a cohort.
  • This dual assessment serves as a complementary test for the detection of the chromosome abnormalities not detected with our current approach, significantly enhancing the accuracy and confidence of the PGT-A test.

What is PGT-A Plus?

  • Building upon our expertise, our latest offering, PGT-A Plus, is a 4-in-1 genetic test which combines our extensively validated in-house Next Generation Sequencing (NGS) technology with an additional and validated targeted Next Generation Sequencing (NGS) strategy using the power of SNPs (Single Nucleotide Polymorphism) without the need for parental samples.
  • This advanced screening solution goes beyond Smart PGT-A by incorporating additional features, including ploidy analysis (complete chromosome sets), DNA contamination detection, and confirmation of genetic relatedness between samples in a cohort, into a standard PGT-A workflow significantly increasing accuracy and confidence in selecting the optimal embryo for transfer.

PGT-A Plus

Our most advanced 4-in-1 genetic test solution

PGT – A

Our custom and validated technology that combines next-generation sequencing (NGS) with advanced algorithms and machine learning, enabling the analysis of genomic data from embryos with exceptional accuracy and reliability.

Genetic PN Check | Ploidy detection

PGT-A Plus enables the detection of both haploidy and triploidy. This crucial assessment ensures the selection of embryos with the correct chromosomal content, minimizing the risk of genetic abnormalities. PGT-A Plus also increases the number of viable euploid embryos available for transfer by detecting true 2PN (diploid) embryos from among morphologically identified 0, 1 and 2.1/3PN embryos.

Cohort check | DNA Fingerprinting

Our quality control process includes Cohort check analysis, where we employ DNA fingerprinting techniques. This ensures accurate identification, differentiation and the assurance that the tested embryo is genetically related to the others in the patient’s cohort reducing the risk of sample mix-ups due to human error.

Detection of DNA Contamination

We have implemented measures to identify and detect both external cell/DNA and maternal cell contamination increasing the accuracy and confidence of the testing process significantly reducing the risk of misdiagnosis.

PGT-A & Smart PGT-A Plus Compared

What is the procedure?

Smart PGT-A Plus uses two independent analysis on every sample to deliver a comprehensive 4-in-1 genetic test for aneuploidy in embryos.

Documentation
  • Smart PGT-A Plus documents

Brochure

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Clinical Sheet

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Features
  • Benefits
  • Indications
  • Test Limitations

What makes our Smart PGT-A Plus stand out from the rest?

Offers enhanced confidence with robust and accurate results, utilizing two independent analyses to detect abnormalities.

Increases the number of viable embryos available for transfer.

Strengthened by the power of big data and artificial intelligence, effectively overcoming the limitations of human subjectivity and greatly reducing the risk of human error.

Enhances accuracy and reduces the risk of misdiagnosis by detecting external and maternal cell DNA contamination.

Maximizes the likelihood of successful pregnancy by carefully identifying optimal embryos for transfer.

Provides confirmation of genetic relatedness between all samples in a cohort without the need for additional parental samples.

Reduces the risk of miscarriage due to previously undetected abnormalities (e.g. triploidy).

Ensures enhanced quality control in the laboratory procedures conducted within your IVF lab, providing greater assurance.

While any couple can have an embryo with aneuploidy, the chances can increase with the following factors:

  • Female age over 35

  • History of recurrent pregnancy loss

  • Previous IVF failure

  • Prior child or pregnancy with a chromosome abnormality

  • Rescue embryos following abnormal fertilization (0PN, 1PN, 2.1PN/3PN)

  • Reproductive history of triploidy/haploidy

  • Complete or partial molar pregnancy

  • The Cohort Check can only be performed for cohorts with 2 or more analyzable embryos. The Cohort Check cannot be performed for embryos with chaotic, haploid or triploid results.
  • The origin of contamination cannot be determined when an admixture of contamination is detected.
  • the origin of the DNA in a sample cannot be determined when the cohort check is inconsistent. Possible explanations include:
    • Complete exogenous contamination.
    • DNA from an unexpected embryo.
    • Biological variability.
  • Smart PGT-A Plus cannot confirm that the correct embryo was transferred.

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  • Patient Journey
    • Before Pregnancy
    • IVF Process
    • Healthy pregnancy
    • After birth
  • Reproductive Health
    • Specialists
      • ERA
      • ERA insight Hub
      • ALICE
      • EMMA
      • EndomeTRIO
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      • PGT-M
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