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      Genomics Precision Diagnostic > Prenatal > Recurrent Pregnancy Loss Precision Panel

      Recurrent Pregnancy Loss Precision Panel

      Recurrent Pregnancy Loss (RPL) is one of the most common obstetric complications, affecting more than 30% of conceptions. These can occur during preimplantation, pre–embryonic, embryonic, early fetal, late fetal and stillbirth. 
      Overview
      Indication
      Clinical Utility
      Genes & Diseases
      Methodology
      References

      Overview

      • Recurrent Pregnancy Loss (RPL) is one of the most common obstetric complications, affecting more than 30% of conceptions. These can occur during preimplantation, pre–embryonic, embryonic, early fetal, late fetal and stillbirth. An important number of losses are due to genetic abnormalities, nonetheless 50% of early pregnancy losses have been associated with chromosomal abnormalities. The majority are due to de novo non–disjunctional events during meiosis and balanced paternal translocations. Traditionally, the assessment of recurrent pregnancy loss was based on karyotyping techniques. However, advances in molecular genetic technology have provided an array of information regarding genetic causes and risk factors for pregnancy loss. One of the most innovative techniques with a significant role in RPL is preimplantation genetic testing in in vitro fertilization cycles.  

      • The Igenomix Recurrent Pregnancy Loss Precision Panel can be used to make a directed and accurate differential diagnosis of inability to carry out a full pregnancy ultimately leading to a better management and achieve a healthy baby at home. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.  

      Indication

      • The Igenomix Recurrent Pregnancy Loss Precision Panel is indicated for those patients the following manifestations: 
        • Inability to conceive after 1 year of unprotected intercourse  
        • Family history of infertility  
        • Personal history of recurrent miscarriages 
        • Family history of recurrent miscarriages 
        • Previous failed IVF cycles 
        • Other failed assisted reproductive technology (ART) treatments 

      Clinical Utility

      The clinical utility of this panel is: 

      • The genetic and molecular confirmation for an accurate clinical diagnosis of a symptomatic patient.  
      • Early initiation of treatment with a multidisciplinary team for an initial consultation, workup and assisted reproductive technologies (ART). 
      • Risk assessment of asymptomatic family members according to the mode of inheritance.

      Genes & Diseases

      Methodology

      References

      See scientific referrals

      age, J., & Silver, R. (2016). Genetic Causes Of Recurrent Pregnancy Loss. Clinical Obstetrics & Gynecology, 59(3), 498-508. Doi: 10.1097/Grf.0000000000000217 

      Crotti, L., Tester, D. J., White, W. M., Bartos, D. C., Insolia, R., Besana, A., Kunic, J. D., Will, M. L., Velasco, E. J., Bair, J. J., Ghidoni, A., Cetin, I., Van Dyke, D. L., Wick, M. J., Brost, B., Delisle, B. P., Facchinetti, F., George, A. L., Schwartz, P. J., & Ackerman, M. J. (2013). Long QT syndrome-associated mutations in intrauterine fetal death. JAMA, 309(14), 1473–1482. https://doi.org/10.1001/jama.2013.3219 

      Rajcan-Separovic E. (2020). Next generation sequencing in recurrent pregnancy loss-approaches and outcomes. European journal of medical genetics, 63(2), 103644. https://doi.org/10.1016/j.ejmg.2019.04.001 

      Tur-Torres, M., Garrido-Gimenez, C., & Alijotas-Reig, J. (2017). Genetics of recurrent miscarriage and fetal loss. Best Practice & Research Clinical Obstetrics & Gynaecology, 42, 11-25. doi: 10.1016/j.bpobgyn.2017.03.007 

      Hyde, K. J., & Schust, D. J. (2015). Genetic considerations in recurrent pregnancy loss. Cold Spring Harbor perspectives in medicine, 5(3), a023119. https://doi.org/10.1101/cshperspect.a023119 

      Sultana, S., Nallari, P., & Ananthapur, V. (2020). Recurrent Pregnancy Loss (RPL): An overview. Journal Of Women’s Health And Development, 03(03). doi: 10.26502/fjwhd.2644-28840038 

      Popescu, F., Jaslow, C., & Kutteh, W. (2018). Recurrent pregnancy loss evaluation combined with 24-chromosome microarray of miscarriage tissue provides a probable or definite cause of pregnancy loss in over 90% of patients. Human Reproduction, 33(4), 579-587. doi: 10.1093/humrep/dey021 

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      • We guide you
        • Fertility
          • What to do if…
        • Prevent Inherited Diseases
          • Carrier Genetic Test
        • Worry-free Pregnancy
          • NACE
          • Prenatal Diagnostics
          • Newborn Health
      • Reproductive Health
        • Specialists
          • ALICE
          • EMMA
          • ERA
          • EndomeTRIO
          • EMBRACE
          • CGT
          • NACE
          • Zenit
          • PGT-A
          • PGT-M
          • POC
          • SAT
          • Newborn Screening
        • Patients
          • ALICE
          • EMMA
          • ERA
          • EndomeTRIO
          • EMBRACE
          • CGT
          • NACE
          • Zenit
          • PGT-A
          • PGT-M
          • SAT
          • POC
      • Diagnostics
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