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Genomics Precision Diagnostic > Metabolic Precision Panel > Methylmalonic Aciduria Precision Panel

Methylmalonic Aciduria Precision Panel

Methylmalonic Aciduria/Acidemia (MMA) is an autosomal recessive disorder of the amino acid metabolism with a defect localized in the conversion of methylmalonyl-coenzyme A (CoA) into succinyl-CoA. 
Overview
Indication
Clinical Utility
Genes & Diseases
Methodology
References

Overview

  • Methylmalonic Aciduria/Acidemia (MMA) is an autosomal recessive disorder of the amino acid metabolism with a defect localized in the conversion of methylmalonyl-coenzyme A (CoA) into succinyl-CoA. The body is therefore unable to process certain proteins and lipids properly. This causes an accumulation of methylmalonic acid in the organisms which manifests in the form of neurologic symptoms such as seizures, encephalopathy, and stroke. It is a lethal, severe heterogeneous disorder involving methylmalonate and cobalamin metabolism with poor prognosis. This disorder can be identified isolated or combined with other organic acidemias. 

  • The Igenomix Methylmalonic Aciduria Precision Panel can be used to make an accurate and directed diagnosis ultimately leading to a better management and prognosis of the disease. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.  

Indication

  • The Igenomix Methylmalonic Aciduria/Acidemia Precision Panel is indicated for those patients with a clinical suspicion or diagnosis with or without the following manifestations: 
    • Vomiting 
    • Dehydration 
    • Lethargy 
    • Seizures 
    • Recurrent infections 
    • Progressive encephalopathy 
    • Hypotonia 
    • Developmental delay 
    • Hepatomegaly 
    • Intellectual disability  

Clinical Utility

The clinical utility of this panel is: 

  • The genetic and molecular confirmation for an accurate clinical diagnosis of a symptomatic patient.  
  • The genetic and molecular confirmation for an accurate clinical diagnosis of a symptomatic patient. 
  • Risk assessment and genetic counselling of asymptomatic family members according to the mode of inheritance. 
  • Improvement of delineation of genotype-phenotype correlation. 

Genes & Diseases

Methodology

References

See scientific referrals

Sloan, J. L., Johnston, J. J., Manoli, I., Chandler, R. J., Krause, C., Carrillo-Carrasco, N., Chandrasekaran, S. D., Sysol, J. R., O’Brien, K., Hauser, N. S., Sapp, J. C., Dorward, H. M., Huizing, M., NIH Intramural Sequencing Center Group, Barshop, B. A., Berry, S. A., James, P. M., Champaigne, N. L., de Lonlay, P., Valayannopoulos, V., … Venditti, C. P. (2011). Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. Nature genetics, 43(9), 883–886. https://doi.org/10.1038/ng.908 

 Matsui, S. M., Mahoney, M. J., & Rosenberg, L. E. (1983). The natural history of the inherited methylmalonic acidemias. New England Journal of Medicine, 308(15), 857-861. doi:10.1056/nejm198304143081501 

Zhou, X., Cui, Y., & Han, J. (2018). Methylmalonic acidemia: Current status and research priorities. Intractable & rare diseases research, 7(2), 73–78. https://doi.org/10.5582/irdr.2018.01026 

Deodato, F., Boenzi, S., Santorelli, F. M., & Dionisi-Vici, C. (2006). Methylmalonic and Propionic Aciduria. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 142C(2), 104-112. doi:10.1002/ajmg.c.30090 

Miousse, I. R., Watkins, D., Coelho, D., Rupar, T., Crombez, E. A., Vilain, E., . . . Rosenblatt, D. S. (2009). Clinical and molecular heterogeneity in patients with the cbld inborn error of cobalamin metabolism. The Journal of Pediatrics, 154(4), 551-556. doi:10.1016/j.jpeds.2008.10.043 

Carrillo-Carrasco, N., Chandler, R. J., & Venditti, C. P. (2011). Combined methylmalonic acidemia And homocystinuria, cblC type. I. Clinical Presentations, diagnosis and management. Journal of Inherited Metabolic Disease, 35(1), 91-102. doi:10.1007/s10545-011-9364-y 

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